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Is it OK to take sertraline at night? You can take sertraline with or without food. You can choose to take sertraline at any time, as long as you stick to the same time every day. If you have trouble sleeping, it's best to take it in the morning. Are generic drugs as effective as brand name? Generic medicines work the same as brand - name medicines A generic medicine is the same as a brand - name medicine in dosage, safety, effectiveness, strength, stability, and quality, as well as in the way it is taken and should be used.
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