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What drug is best for acid reflux? What medications are used to treat acid reflux disease? Foaming agents (Gaviscon) coat your stomach to prevent reflux. H2 blockers (Pepcid, Tagamet, Zantac) decrease acid production. Proton pump inhibitors (Prilosec, Prevacid, Protonix, Aciphex, Nexium) also reduce the amount of acid your stomach makes.
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