although precise ligands remain unknown. Gonococcal strains lacking AccA or any conserved His and Met residue in AccA fail to grow and reduce NO2 . The theoretical basis for the non ideal Arrhenius temperature kinetics of this enzyme was also studied and its behaviour was described in terms of a thermodynamic equilibrium between a high temperature active state and a low temperature inactive state. The sigmoidal response of the enzyme to increasing potassium ion concentrations was quantified in terms of its stoichiometric requirement for two moles of potassium ion per mole of ATP hydrolysed. The effects of lipid targeted and protein targeted modulators on the kinetic properties of the NA(^+) K(^+) ATPase were studied. The analysis is based upon extended
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