might be associated with intraoperative oxygen administration and outcomes. Missing data for covariates were addressed with multiple imputation and the chained equations method with predictive mean matching to generate five datasets with complete covariate information.27 Statistical analyses were implemented separately for each completed dataset with results pooled using Rubin's rules.28 The effects of quantitative variables were modeled using a flexible splines method with quantitative and graphical regression diagnostics examined to evaluate the suitability of constructed models and any nonlinear effects.
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