these have not been yet characterized and the Leishmania serinome remains surprisingly neglected. This project attempts map and explore therapeutic targets within SHs present in the Leishmania proteome using an activity based protein profiling (ABPP) strategy in the quest to find new protein drug targets for drug discovery. Initial experiments using commercial fluorophosphonate (FPs) probes revealed significant differences between the SH expression levels throughout their life cycles and between different Leishmania spp.
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