supraphysiological oxygen administration was defined as the area under the curve of FIO2 above 21% during minutes when the corresponding SpO2 was >92% (AUCFIO2). We excluded minutes when the SpO2 was 92% because current guidelines recommend targeting an SpO2 >92% and increased FIO2 during these minutes might be required to achieve appropriate blood oxygen levels and therefore not considered in excess.1617 For minutes when the FIO2 or SpO2 was missing for up to five minutes
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